5 ESSENTIAL ELEMENTS FOR NR1-SITE

Using this solution, Kalbaugh et al. assigned affinity and efficacy roles to positions while in the LBDs in the NR1 and NR2A NMDAR subunits. In situ mutation of residues in direct connection with sure ligand affected both equally efficacy and affinity, although positions that stabilize the closed cleft conformation and not using a immediate ligand